38th Scientific Meeting (GV - SOLAS)
Society for Laboratory Animal Science

Seminar on Isolated Perfused Organs
(Essen, 2000)
     
   


  General Aspects  
  Mucous Membrane  
  Skin  
  Lung  
  Udder  
  Bone  
  Kidney  
  Liver  
  Uterus
 
  Intestines  


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Abstracts
       
 
 
Abstracts
 
Titles only
 
   
   
   
   
   
   
   
 
 
  W. Pittermann: Proceedings 1998: more...  

Essen, 2000

-Mucous Membrane

In-vitro assay for the local compatibility in skin and mucous membranes: Testing of market products, ingredients, household- and process chemicals
Pittermann W., Förster T., B. Blume and M. Kietzmann
Henkel KGaA, D40191 Duesseldorf

(see also Skin - Abstract 4)

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- Skin

Abstract 1

The ´with blood perfused pig ear´; a model for studying interactions between chemicals and the skin
Graham R. Elliott
Dept. Pharmacology, TNO Prins Maurits Laboratorium, Postbus 45, 2280 AA, Rijswijk, NL

Abstract 2

The use of the reflexion spectroscopy to study the distribution of carotinoids into the skin of the isolated perfused bovine udder
F. Niedorf (1), H. Jungmann (2), W. Pittermann (3), M. Kietzmann (1)
(1) Institute for Pharmacology, Pharmacy and Toxicology, Veterinary School Hannover, D-30559 Hannover (2) MBR Meßtechnik GmbH, D-58313 Herdecke, (3) Henkel KGaA, D40191 Duesseldorf

Abstract 3

Opportunities of the BUS-model during development and characterisation of transdermal systems using estradiol-17ß
Wolff M., Kluge K., Arth C, Bonn R. and M. Kietzmann
Schwarz Pharma AG, Alfred-Nobel-Straße 10, D-40789 Monheim Institute for Pharmacology, Pharmacy and Toxicology, Veterinary School Hannover, D-30559 Hannover

Abstract 4

In-vitro assay for the local compatibility in skin and mucous membranes: Testing of market products, ingredients, household- and process chemicals
Pittermann W., Förster T., B. Blume and M. Kietzmann
Henkel KGaA, D40191 Duesseldorf

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- Lung

Abstract 1

An alternative investigation method for animal experiments in ischemia/reperfusion injury. The use of pig lungs and blood from slaughterhouse for isolated organ perfusion
v. Engelhardt A. (1), Dittrich S. (2), Lippek F. (3), Hegemann O. (2), Koios D. (2), v.d. Gröben J. (2), Grosse-Siestrup Ch. (1,4) and Lange, P. (2)
Department of Animal Experiments (1), the Pathological Institute (3), Charité, Campus Virchow-Clinics and the Department of Congenital Heart Disease, Deutsches Herzzentrum (2), Berlin, Humboldt University of Berlin and Mediport Biotechnik Berlin (4)

Abstract 2

Assessment of the acute pulmonary toxicity of lamp oils (paraffin oil, Edenor ME 12 70, Edenor LPL) in perfused rat lungs
S. Uhlig and R. Göggel
Research Center Borstel, D-28845 Borstel

Abstract 3

In vitro studies on airway hyperreactivity in mice using isolated perfused lungs and precision-cut lung slices
H.-D. Held, A. Wohlsen, Ch. Martin and S. Uhlig
Division Pulmonary Pharmacology, Research Center Borstel, D-28845 Borstel

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- Udder

Abstract 1

Tissue distribution of "systemically" administered antibiotics in the isolated perfused bovine udder
A.M. Ehinger, B. Blume and M. Kietzmann
Institute for Pharmacology, Pharmacy and Toxicology, Veterinary School Hannover, D-30559 Hannover

Abstract 2

The use of microdialysis technique for isolated perfused organs
W. Bäumer, M. Kietzmann
Institute for Pharmacology, Pharmacy and Toxicology, Veterinary School Hannover, D-30559 Hannover

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- Bone

The isolated perfused canine leg used as a model studying the influx of drugs into the osseous tissue
M. Vick,. A.M. Ehinger and M. Kietzmann
Institute for Pharmacology, Pharmacy and Toxicology, Veterinary School Hannover, D-30559 Hannover

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- Kidney


Abstract 1

Effects of Different Perfusates on Functional Parameters of Isolated Perfused Dog Kidneys

Höchel J., Lehmann D., Große-Siestrup C. Fehrenberg C., and H. Hartmann
Institute of Transfusion Medicine and Immunhaematology and Animal Experimental Facilities of Charite´, Campus Virchow Klinikum, Humboldt University, Berlin, Germany

Abstract 2

Isolated Pig Kidney Perfusion: 4-hour-cold-Preservation Superior to Fresh Harvested Unpreserved
Unger V., von Baeyer H., Große-Siestrup C.
Institute of Transfusion Medicine and Immunhaematology and Animal Experimental Facilities of Charite´, Campus Virchow Klinikum, Humboldt University, Berlin, Germany

Abstract 3

Renal Ischaemia-Reperfusion Injuries - Influence of Species and Age on Functional Parameters in the Isolated Perfused Kidney from Dogs and Pigs
Höchel J, Unger V, Dittrich S. Lehmann D. Große-Siestrup C. Fehrenberg, C. Harmann H.
Institute of Transfusion Medicine and Immunhaematology and Animal Experimental Facilities of Charite´, Campus Virchow Klinikum, Humboldt University, Berlin, Germany

Abstract 4

New experiences with xenoperfusion by the use of a pig- to- human setting
Aslan T, Grosse- Siestrup C, Unger V, von Baeyer H., Salama A.
Institute of Transfusion Medicine and Immunhaematology and Animal Experimental Facilities of Charite´, Campus Virchow Klinikum, Humboldt University, Berlin, Germany

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- Liver

The isolated haemoperfused porcine liver - Effects of Polidocanol and Diclofenac
J. Pfeffer, P. Wevers, K. Leiterer, S. Nagel, C. Große-Siestrup et al.
Institute of Transfusion Medicine and Immunhaematology and Animal Experimental Facilities of Charite´, Campus Virchow Klinikum, Humboldt University, Berlin, Germany

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- Uterus


The isolated perfused bovine uterus as a model for mucous membrane irritancy and inflammation
W. Bäumer, A. Mertens, M. Braun, M. Kietzmann
Institute for Pharmacology, Pharmacy and Toxicology, Veterinary School Hannover, D-30559 Hannover

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-Intestines

Cost-effective screening for oral bioavailability using the isolated perfused rat intestine
Nicholas D. Kerwin, Stuart G. Wood
BioDynamics Research Limited, Milton Keynes, UK

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- General Aspects

Isolated organ systems used in contract research labs
Heydeck D.
Mediport Biotechnik GmbH, D-12247 Berlin

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Hamburg, 1998 www.gv-solas.de ISBN 0-901334-12-X
(1st Workshop)

- Mucous Membrane

W.F.Pittermann, Th. Förster, M. Schmitt and M. Kietzmann (Düsseldorf/Hannover)
The Bovine Udder System (BUS-model) in cosmetic research


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- Skin

T. Ludewig (Leipzig)
The morphology of the bovine udder skin


M. Kietzmann, B.Blume and V.-M.Itzel-Kietzmann (Hannover)
The isolated perfused bovine udder as a model of transdermal penetration and absorption of drugs

W.F.Pittermann, Th. Förster, M. Schmitt and M. Kietzmann (Düsseldorf/Hannover)
The Bovine Udder System (BUS-model) in cosmetic research

W.Bäumer, M.Kietzmann (Hannover)
Effects of steroidal and nonsteroidal drugs an eicosanoid synthesis in the skin of the isolated perfused bovine udder


H.Jungmann, M.Bittner and M.Schietzel (Herdecke)
Visible and NIR-spectroscopy dermatological applications under in-vivo and in-vitro studies


I.Riebeling, A.deRoux, M.Meiler and Ch.Große-Siestrup (Berlin)
Isolated warm hemoperfused porcine leg - a model for testing transdermal resorption

H. P. Klöcking (Erfurt)
The isolated perfused pig ear — a tool of testing substances for t-PA release
(Editor: Use of vascular system of the pig ear)

G.Patone, R.Knüppel and Ch.Große-Siestrup (Berlin)
Extracorporal modular circulation for the perfusion of isolated organs of large mammals (pigs)


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- Lung

S.Uhlig, H.D.Held and R.Göggel (Borstel)
Applications of isolated perfused lungs

Ch.Martin, S.Uhlig (Borstel)
Lung functions in precision-cut lung slices

C.Fehrenberg, H.von Baeyer, V.Unger, M.Meissler and Ch.Große-Siestrup (Berlin) Special aspects of organ harvesting, preservation and quality control for the isolated hemoperfusion of porcine slaughterhouse organs

S.Dittrich, I.Dähnert, A.von Engelhardt, D.Koios, O.Hegemann, M.Meissler, Ch.Große-Siestrup and P.E.Lange (Berlin) The isolated perfused pig lung - gas exchange measurements for assessment of lung function

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- Mammary Gland

A.M.Ehinger, M.Kietzmann (Hannover)
Studies concerning the tissue distribution of locally (intracisternally) administered antibiotics in the isolated perfused bovine udder


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- Heart

C.Fehrenberg, H.von Baeyer, V.Unger, M.Meissler and Ch.Große-Siestrup (Berlin)
Special aspects of organ harvesting, preservation and quality control for the isolated hemoperfusion of porcine slaughterhouse organs

G.Patone, R.Knüppel and Ch.Große-Siestrup (Berlin) Extracorporal modular circulation for the perfusion of isolated organs of large mammals (pigs)

St.Eddicks, M.Vavelidis, D.Stolte, I.Ast, D.Modersohn, K.P.Leiterer and Ch.Große-Siestrup (Berlin) The isolated normothermic hemoperfused pig heart - measurement of the global and regional heart function

D.Stolte, I.Ast, St.Eddicks, M.Vavelidis, D.Modersohn, K.P.Leiterer and Ch.Große-Siestrup (Berlin) The isolated normothermic hemoperfused pig heart - measurement of metabolic parameters for the assessment of heart function

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- Kidney

C.Fehrenberg, H.von Baeyer, V.Unger, M.Meissler and Ch.Große-Siestrup (Berlin)
Special aspects of organ harvesting, preservation and quality control for the isolated hemoperfusion of porcine slaughterhouse organs


J.von Loeper, S.Dittrich, H.Aurich, F.Lippek, A.Schuth, M.Meissler and P.E. Lange (Berlin) Physiological characterization of cold storage after cadaver explantation in the isolated perfused pig kidney

V.Unger, H.von Baeyer and Ch.Große-Siestrup (Berlin)
Hemoperfused porcine kidney as a valid pharmacological furosemide


K.Stahl, E.Neew-Galuschka, M.Meissler, H.von Baeyer, Ch.Große-Siestrup and G.Kaczmarczyk (Berlin)
Inhibition of ANG II reduces sodium excretion in isolated perfused kidneys

E.Neew-Galuschka, K.Stahl, C.Fehrenberg and G.Kaczmarczyk (Berlin)
Pathophysiology of the isolated blood-perfused porcine kidney - better understanding of the Renin-Angiotensin-System


H.Aurich, S.Dittrich, A.Schuth, J.von Loeper, M.Meissler, Ch.Große-Siestrup and P.E.Lange (Berlin)
Effects of sodium nitroprusside and norepinephrine an the isolated pig kidney


F.Lippek, G.Holland, K.Stahl, Ch.Große-Siestrup and H.von Baeyer (Berlin)
The hyperacute rejection in a xenoperfusion model of pig kidney


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- Liver

C.Fehrenberg, H.von Baeyer, V.Unger, M.Meissler and Ch.Große-Siestrup (Berlin) Special aspects of organ harvesting, preservation and quality control for the isolated hemoperfusion of porcine slaughterhouse organs

S.Sprenger, C.Fehrenberg, Ch.Große-Siestrup, H.von Baeyer, O.Holberndt and K.Affeld (Berlin) Porcine liver harvesting and perfusion in a refined perfusion system First results


- Eye

G.Niemeyer, N.Kueng, and N.Lansel (Zürich)
Neurobiology and experimental use of the in vitro perfused mammalian eye


- Intestines

C.Fehrenberg, H.von Baeyer, V.Unger, M.Meissler and Ch.Große-Siestrup (Berlin) Special aspects of organ harvesting, preservation and quality control for the isolated hemoperfusion of porcine slaughterhouse organs


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August 6, 2000 Copyright © 2000 (UNI - Klinikum Essen, Prof. Dr. Klaus Militzer; Organization Committee)