38th Scientific
Meeting (GV - SOLAS)
Society for Laboratory Animal Science
(Essen, 2000)
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38th Scientific
Meeting (GV - SOLAS) |
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(Essen, 2000) |
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Bone The isolated perfused canine leg used as a model studying the influx of drugs into the osseous tissue M. Vick,. A.M. Ehinger and M. Kietzmann Institute for Pharmacology, Pharmacy and Toxicology, Veterinary School Hannover, D-30559 Hannover Pharmacokinetic studies of the tissue distribution of drugs are often limited by ethical considerations. Because it is not possible to measure drug concentrations in body tissues without surgical procedures, the use of isolated perfused organs may be advantageous. Therefore, the isolated perfused canine leg was introduced as an in vitro model for studies of the drug distribution into the bone tissue. Legs from euthanasised dogs are perfused with a saline solution (Tyrode). In first pharmacokinetic studies, the influx of the fluoroquinolones enrofloxacin and ciprofloxacin into the bone tissue was measured after addition of the compounds to the perfusion fluid. top |
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| August 6, 2000 | Copyright
© 2000 (UNI - Klinikum |
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